Cade was the first to report the anti-manic effect of lithium, and by the late 1960s its role in the prophylaxis of bipolar disorder was established. 1 In the next decade it became widely used on
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But perhaps what is truly remarkable is the fact that lithium has recently strengthened its clinical profile in the pharmacological armamentarium presently used to treat bipolar disorder. 4 This
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From the 1950s, intrigued by Cade''s results and in order to help his brother, who had bipolar disorder, he described the preventive effect of lithium in manic-depressive illness.
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John Frederick Joseph Cade (1912–1980) was an Australian psychiatrist best known for his discovery of lithium as an effective treatment for bipolar disorder (formerly known as manic-depressive illness).
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The Danish psychiatrist was as much a hero as Cade, fighting long and hard to get lithium accepted as a treatment for bipolar disorder. He knew the condition intimately, because his
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John Cade can be recognized as the pioneer of modern lithium therapy. After the experiments on guinea pigs and his lithium intake, he described the therapeutic effect of lithium in ten
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In the decades since its publication, Cade''s article has been widely cele-brated as a significant milestone which facilitated an enormous leap forward in the treatment of bipolar disorder.
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However, advancements in psychiatric research eventually led to the discovery of lithium as a groundbreaking treatment option for bipolar disorder. This chapter explores the historical
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His meticulous experiments and willingness to challenge conventional wisdom led to the first effective pharmacological treatment for bipolar disorder. Cade''s legacy is visible today in the
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